BDBM537439 N-methyl-1-((1s,4s)-4-((1- methyl-5-(trifluoromethyl)- 1H-pyrazol-4- yl)oxy)cyclohexyl)-3-(4-((4- methylpiperazin-1- yl)methyl)phenyl)-1H- pyrazolo[4,3-c]pyridin-6- amine::US11247990, Example 264

SMILES CNc1cc2n(nc(-c3ccc(CN4CCN(C)CC4)cc3)c2cn1)C1CC[C@@H](CC1)Oc1cnn(C)c1C(F)(F)F

InChI Key InChIKey=CFTDNZWOFQLTNX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 537439   

TargetTyrosine-protein kinase receptor UFO(Human)
Array Biopharma

US Patent
LigandPNGBDBM537439(US11247990, Example 264 | N-methyl-1-((1s,4s)-4-((...)
Affinity DataIC50: 20nMAssay Description:AXL: Compounds of Formula I were screened for their ability to inhibit AXL kinase using Invitrogen's LanthaScreen Eu Kinase Binding technology. H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
Array Biopharma

US Patent
LigandPNGBDBM537439(US11247990, Example 264 | N-methyl-1-((1s,4s)-4-((...)
Affinity DataIC50: 20nMAssay Description:MER: Compounds of Formula I were screened for their ability to inhibit MER kinase using Invitrogen's LanthaScreen Eu Kinase Binding technology. H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Array Biopharma

US Patent
LigandPNGBDBM537439(US11247990, Example 264 | N-methyl-1-((1s,4s)-4-((...)
Affinity DataIC50: 110nMAssay Description:TYRO3: Compounds of Formula I were screened for their ability to inhibit TYRO3 kinase using Invitrogen's LanthaScreen Eu Kinase Binding technolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent