BDBM538634 NCGC 00371957::US11254667, Compound I-40::US11542261, Compound I-40

SMILES Clc1cn2c(cnc2cc1OCCN1CCOCC1)-c1cccc(NC2CCNC2)n1

InChI Key InChIKey=WHDGQRKUPDYCCN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 538634   

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM538634(NCGC 00371957 | US11254667, Compound I-40 | US115...)
Affinity DataIC50: 8nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM538634(NCGC 00371957 | US11254667, Compound I-40 | US115...)
Affinity DataIC50: 8nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2022
Entry Details
US Patent

TargetGTPase NRas(Human)
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM538634(NCGC 00371957 | US11254667, Compound I-40 | US115...)
Affinity DataIC50: 626nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2022
Entry Details
US Patent

TargetGTPase NRas(Human)
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM538634(NCGC 00371957 | US11254667, Compound I-40 | US115...)
Affinity DataIC50: 626nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
US Patent