BDBM539192 4-(3-((R)-3-aminopiperidine-1-carbonyl)- 1-(2-fluoro-4-((S)-3-fluoropyrrolidine-1- yl)phenyl)-1H-pyrazole-5-yl)-2-fluorobenzo- nitrile::US11254676, Example 62

SMILES N[C@@H]1CCCN(C1)C(=O)c1cc(-c2ccc(C#N)c(F)c2)n(n1)-c1ccc(cc1F)N1CC[C@H](F)C1

InChI Key InChIKey=CXCBOBSQBMFELB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 539192   

TargetLysine-specific histone demethylase 1A(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM539192(4-(3-((R)-3-aminopiperidine-1-carbonyl)- 1-(2-fluo...)
Affinity DataIC50: 41nMAssay Description:The biochemical inhibition activity of the synthesized compounds on LSD1 was measured. The activity measurement was performed using LSD1 fluorescence...More data for this Ligand-Target Pair
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Date in BDB:
6/19/2022
Entry Details
US Patent