BDBM5392 1-{4-[(3-methyl-5-{[4-(2-phenyl-1H-imidazol-1-yl)pyrimidin-2-yl]amino}phenyl)methyl]piperazin-1-yl}ethan-1-one::2,4-Disubstituted Pyrimidine 3d

SMILES CC(=O)N1CCN(Cc2cc(C)cc(Nc3nccc(n3)-n3ccnc3-c3ccccc3)c2)CC1

InChI Key InChIKey=DSBLOQJREHHYBA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5392   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5392(1-{4-[(3-methyl-5-{[4-(2-phenyl-1H-imidazol-1-yl)p...)
Affinity DataIC50: 32nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2005
Entry Details Article
PubMed