BDBM539916 3-chloro-4- (((3R,4S)-3- hydroxy-3- (hydroxymethyl)- 4-((4- (trifluoromethyl) phenyl)sulfonyl) pyrrolidin-1- yl)sulfonyl)benzonitrile::US11260049, Ex. 54

SMILES OC[C@]1(O)CN(C[C@@H]1S(=O)(=O)c1ccc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1Cl)C#N

InChI Key InChIKey=HTTGTURMCLWJTN-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 539916   

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM539916(3-chloro-4- (((3R,4S)-3- hydroxy-3- (hydroxymethyl...)
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent