BDBM539932 4-(((3S,4R)-1- ((4-cyano-2-methyl- phenyl)sulfonyl)- 4-hydroxy-4- (hydroxymethyl) pyrrolidin-3- yl)sulfonyl)-2- fluorobenzonitrile::US11260049, Ex. 70

SMILES Cc1cc(ccc1S(=O)(=O)N1C[C@@H]([C@](O)(CO)C1)S(=O)(=O)c1ccc(C#N)c(F)c1)C#N

InChI Key InChIKey=HFHFGSWWOZIHDF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 539932   

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM539932(4-(((3S,4R)-1- ((4-cyano-2-methyl- phenyl)sulfonyl...)
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent