BDBM539936 4-(((3R,4S)-4-((4-bromophenyl)sulfonyl)-3-hydroxy-3-(hydroxymethyl)pyrrolidin-1-yl)sulfonyl)-3-chlorobenzonitrile::US11260049, Ex. 74

SMILES OC[C@]1(O)CN(C[C@@H]1S(=O)(=O)c1ccc(Br)cc1)S(=O)(=O)c1ccc(cc1Cl)C#N

InChI Key InChIKey=UOLCQJALMSULDJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 539936   

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM539936(4-(((3R,4S)-4-((4-bromophenyl)sulfonyl)-3-hydroxy-...)
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent