BDBM539949 4-(((3S,4R)-1- ((2,4- dichlorophenyl) sulfonyl)-4- hydroxy-4- (hydroxymethyl) pyrrolidin-3- yl)sulfonyl)-2,6- difluorobenzonitrile::US11260049, Ex. 87

SMILES OC[C@]1(O)CN(C[C@@H]1S(=O)(=O)c1cc(F)c(C#N)c(F)c1)S(=O)(=O)c1ccc(Cl)cc1Cl

InChI Key InChIKey=JYOSLWOOCLLKSB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 539949   

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM539949(4-(((3S,4R)-1- ((2,4- dichlorophenyl) sulfonyl)-4-...)
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent