BDBM539969 3-chloro-4- (((3R,4S)-4-((4- chloro-3- fluorophenyl) sulfonyl)-3- hydroxy-3- (hydroxymethyl) pyrrolidin-1- yl)sulfonyl)benzo nitrile::US11260049, Ex. 107

SMILES OC[C@]1(O)CN(C[C@@H]1S(=O)(=O)c1ccc(Cl)c(F)c1)S(=O)(=O)c1ccc(cc1Cl)C#N

InChI Key InChIKey=FTRZGPXZCAQDIT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 539969   

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM539969(3-chloro-4- (((3R,4S)-4-((4- chloro-3- fluoropheny...)
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
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Date in BDB:
6/24/2022
Entry Details
US Patent