BDBM539979 2-(((3R,4S)-4-((4- chlorophenyl) sulfonyl)-3- hydroxy-3- (hydroxymethyl) pyrrolidin-1- yl)sulfonyl)-5- (trifluoromethyl) benzonitrile::US11260049, Ex. 117

SMILES OC[C@]1(O)CN(C[C@@H]1S(=O)(=O)c1ccc(Cl)cc1)S(=O)(=O)c1ccc(cc1C#N)C(F)(F)F

InChI Key InChIKey=NYSOYBHHKXZKAL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 539979   

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM539979(2-(((3R,4S)-4-((4- chlorophenyl) sulfonyl)-3- hydr...)
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent