BDBM539988 4-(((3S,4S)-3- (aminomethyl)-4- ((4-chlorophenyl) sulfonyl)-3- hydroxypyrrolidin- 1-yl)sulfonyl) benzonitrile::US11260049, Ex. 126

SMILES NC[C@]1(O)CN(C[C@@H]1S(=O)(=O)c1ccc(Cl)cc1)S(=O)(=O)c1ccc(cc1)C#N

InChI Key InChIKey=AVVFJEZVPHMSAF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 539988   

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM539988(4-(((3S,4S)-3- (aminomethyl)-4- ((4-chlorophenyl) ...)
Affinity DataIC50: 55nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent