BDBM539991 3-chloro-4-(((4S,5R)-4-((5-chloropyridin-2-yl)sulfonyl)-6-oxa-2,9-diazaspiro[4.5]decan-2-yl)sulfonyl)benzonitrile, Hydrochloride::US11260049, Ex. 129

SMILES Clc1ccc(nc1)S(=O)(=O)[C@H]1CN(C[C@]11CNCCO1)S(=O)(=O)c1ccc(cc1Cl)C#N

InChI Key InChIKey=BJCWKEUJFNATJV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 539991   

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property (No. 2)

US Patent
LigandPNGBDBM539991(3-chloro-4-(((4S,5R)-4-((5-chloropyridin-2-yl)sulf...)
Affinity DataIC50: 55nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2022
Entry Details
US Patent