BDBM5413 1-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl]phenoxy}ethyl)piperidine::pyrazolo[1,5-a]pyrimidine 4e

SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1

InChI Key InChIKey=VOYMOBPSYVKQGF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 5413   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5413(1-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5413(1-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5413(1-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5413(1-(2-{4-[3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin...)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrate by ECMAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details Article
PubMed