BDBM5417 4-[6-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]pyridine::pyrazolo[1,5-a]pyrimidine 1a

SMILES c1nn2cc(cnc2c1-c1ccncc1)-c1ccncc1

InChI Key InChIKey=ZLISHOMLHVNDJG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5417   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5417(4-[6-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]p...)
Affinity DataIC50: 224nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5417(4-[6-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]p...)
Affinity DataIC50: 224nMAssay Description:Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details Article
PubMed