BDBM542488 2-(cyclobutylamino)-N-(2-hydroxy-3-{1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl}propyl)-6-(4-methylpiperazin-1-yl)pyridine-4-carboxamide::US11274098, Example 2

SMILES CN1CCN(CC1)c1cc(cc(NC2CCC2)n1)C(=O)NCC(O)CN1CCc2[nH]c3ccccc3c2C1

InChI Key InChIKey=IOXCOBDKZWKUOO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 542488   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM542488(2-(cyclobutylamino)-N-(2-hydroxy-3-{1H,2H,3H,4H,5H...)
Affinity DataIC50: 771nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the 1050 activity of PRMT5. Biotinylated histone peptides were synthesized and attached to 384-wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent