BDBM542489 6-(cyclobutylamino)-N-(2-hydroxy-3-{1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl}propyl)pyrimidine-4-carboxamide::US11274098, Example 3

SMILES OC(CNC(=O)c1cc(NC2CCC2)ncn1)CN1CCc2[nH]c3ccccc3c2C1

InChI Key InChIKey=XFGGRVYEXSACGG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 542489   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM542489(6-(cyclobutylamino)-N-(2-hydroxy-3-{1H,2H,3H,4H,5H...)
Affinity DataIC50: 1.69E+3nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the 1050 activity of PRMT5. Biotinylated histone peptides were synthesized and attached to 384-wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent