BDBM542491 N-(2-hydroxy-3-{1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl}propyl)-4-({3-oxa-8-azabicyclo[3.2.1]octan-8-yl}carbonyl)benzamide::US11274098, Example 5

SMILES OC(CNC(=O)c1ccc(cc1)C(=O)N1C2CCC1COC2)CN1CCc2[nH]c3ccccc3c2C1

InChI Key InChIKey=CTSDFYHWEZHHFR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 542491   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM542491(N-(2-hydroxy-3-{1H,2H,3H,4H,5H-pyrido[4,3-b]indol-...)
Affinity DataIC50: 1.73E+3nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the 1050 activity of PRMT5. Biotinylated histone peptides were synthesized and attached to 384-wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent