BDBM542492 6-(cyclobutylamino)-N-(2-hydroxy-3-{5-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl}propyl)-2-(4-methylpiperazin-1-yl)pyrimidine-4-carboxamide::US11274098, Example 6

SMILES CN1CCN(CC1)c1nc(NC2CCC2)cc(n1)C(=O)NCC(O)CN1CCc2c(C1)c1ccccc1n2C

InChI Key InChIKey=LBLZEQOHSQDSPR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 542492   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM542492(6-(cyclobutylamino)-N-(2-hydroxy-3-{5-methyl-1H,2H...)
Affinity DataIC50: 108nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the 1050 activity of PRMT5. Biotinylated histone peptides were synthesized and attached to 384-wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent