BDBM542494 N-(2-hydroxy-3-{5-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl}propyl)-4-({3-oxa-8-azabicyclo[3.2.1]octan-8-yl}carbonyl)benzamide::US11274098, Example 8

SMILES Cn1c2CCN(CC(O)CNC(=O)c3ccc(cc3)C(=O)N3C4CCC3COC4)Cc2c2ccccc12

InChI Key InChIKey=BMVWYOJMXCGYLS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 542494   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM542494(N-(2-hydroxy-3-{5-methyl-1H,2H,3H,4H,5H-pyrido[4,3...)
Affinity DataIC50: 3.34E+3nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the 1050 activity of PRMT5. Biotinylated histone peptides were synthesized and attached to 384-wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent