BDBM542506 2-hydroxy-3-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)propyl 3-phenylpyrrolidine-1-carboxylate::US11274098, Example 20

SMILES OC(COC(=O)N1CCC(C1)c1ccccc1)CN1CCc2c(C1)[nH]c1ccccc21

InChI Key InChIKey=HINOGIPUFJLPAK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 542506   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM542506(2-hydroxy-3-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]in...)
Affinity DataIC50: 1.05E+4nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the 1050 activity of PRMT5. Biotinylated histone peptides were synthesized and attached to 384-wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent