BDBM542514 6-((1-acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide::US11274098, Example 28

SMILES CC(=O)N1CCC(CC1)Nc1cc(ncn1)C(=O)NCC(O)CN1CCn2c(C1)cc1ccccc21

InChI Key InChIKey=FWEDLOSNMZRUNG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 542514   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM542514(6-((1-acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydr...)
Affinity DataIC50: 45nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the 1050 activity of PRMT5. Biotinylated histone peptides were synthesized and attached to 384-wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent