BDBM543870 (1S,3'R,6'S,7'S,11'S,12'R)- 6-chloro-7'-((4-(2- methoxyethyl)-3-oxo-1- piperazinyl)methyl)- 11',12'-dimethyl-3,4- dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]di- azatetracyclo[14.7.2.0~3, 6~.0~19,24~]pentacosa 16,18,24]trien]-15'-one 13,13'-dioxide AND::US11279712, Example 3::US11279712, Example 7

SMILES COCCN1CCN(C[C@H]2CCC[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c3ccc4OC[C@]5(CCCc6cc(Cl)ccc56)CN(C[C@@H]5CC[C@@H]25)c4c3)CC1=O

InChI Key InChIKey=GZTJFAOLVBZXHW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 543870   

LigandPNGBDBM543870(US11279712, Example 7 | (1S,3'R,6'S,7'S,11'S,12'R)...)
Affinity DataIC50: 0.181nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent

LigandPNGBDBM543870(US11279712, Example 7 | (1S,3'R,6'S,7'S,11'S,12'R)...)
Affinity DataIC50: 0.257nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent