BDBM543871 (1S,3'R,6'S,7'S,11'S,12'R)- 7'-(((9aS)-8- acetyloctahydro-2H- pyrazino[1,2-a]pyrazin- 2-yl)methyl)-6-chloro- 11',12'-dimethyl-3,4- dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]di- azatetracyclo[14.7.2.0~3, 6~.0~19,24~]pentacosa [16,18,24]trien]-15'-one 13',13'-dioxide OR::US11279712, Example 15::US11279712, Example 25::US11279712, Example 35::US11279712, Example 4::US11279712, Example 48

SMILES C[C@H]1CCC[C@H](CN2CCN3CCN(C[C@@H]3C2)C(C)=O)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C

InChI Key InChIKey=ROIWWOCSOOXBFV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 543871   

LigandPNGBDBM543871(US11279712, Example 15 | US11279712, Example 48 | ...)
Affinity DataIC50: 0.212nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

LigandPNGBDBM543871(US11279712, Example 15 | US11279712, Example 48 | ...)
Affinity DataIC50: 0.185nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

LigandPNGBDBM543871(US11279712, Example 15 | US11279712, Example 48 | ...)
Affinity DataIC50: 0.252nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

LigandPNGBDBM543871(US11279712, Example 15 | US11279712, Example 48 | ...)
Affinity DataIC50: 0.0500nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent

LigandPNGBDBM543871(US11279712, Example 15 | US11279712, Example 48 | ...)
Affinity DataIC50: 0.329nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
Go to US Patent