BDBM543875 (1s,3′r,6′r,7′r,11's,12′r)-6-chloro-11′,12′-dimethyl-7′-(4-morpholinylcarbonyl)-3,4-dihydro-2h,15′h-spiro[naphthalene-1,22′-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.0˜3,6˜0.0˜19,24˜]pent acosa[16,18,24]trien]-15′-one 13′,13′-dioxide::US11279712, Example 8

SMILES C[C@H]1CCC[C@H]([C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C)C(=O)N1CCOCC1

InChI Key InChIKey=KRLPTSFXJDMYDJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 543875   

LigandPNGBDBM543875((1s,3′r,6′r,7′r,11's,12′r)...)
Affinity DataIC50: 0.126nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2022
Entry Details
US Patent