BDBM543876 (1S,3'R,6'R,7'S,11'S,12'R)- 7'-(1- azetidinylcarbonyl)-6- chloro-11',12'-dimethyl- 3,4-dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]di- azatetracyclo[14.7.2.0~3, 6~.0~19,24~]pentacosa [16,18,24]trien]-15'-one 13',13'-dioxide OR::US11279712, Example 9
SMILES C[C@H]1CCC[C@@H]([C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C)C(=O)N1CCC1
InChI Key InChIKey=AMECMJWYUNUICP-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 543876
TargetBcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 0.246nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair