BDBM543878 (1S,3'R,6'R,7'S,11'S,12'R)- 6-chloro-N-(2- methoxyethyl)-11',12'- dimethyl-15'-oxo-3,4- dihydro-2H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]di- azatetracyclo[14.7.2.0~3, 6~.0~19,24~]pentacosa [16,18,24]trien]-7'- carboxamide 13',13'- dioxide Or::US11279712, Example 11

SMILES COCCNC(=O)[C@H]1CCC[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=MGOIXHIVHWVNKW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 543878   

LigandPNGBDBM543878((1S,3'R,6'R,7'S,11'S,12'R)- 6-chloro-N-(2- methoxy...)
Affinity DataIC50: 0.237nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
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Date in BDB:
7/10/2022
Entry Details
US Patent