BDBM543905 (1S,3'R,6'R,7'S,11'S,12'R)- 6-chloro-7'-((3,3- difluoro-1- azetidinyl)carbonyl)- 11',12'-dimethyl-3,4- dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]di- azatetracyclo[14.7.2.0~3, 6~.0~19,24~]pentacosa [16,18,24]trien]-15'-one 13',13'-dioxide OR::US11279712, Example 38

SMILES C[C@H]1CCC[C@@H]([C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C)C(=O)N1CC(F)(F)C1

InChI Key InChIKey=IUJHLNNVDAROKQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 543905   

LigandPNGBDBM543905((1S,3'R,6'R,7'S,11'S,12'R)- 6-chloro-7'-((3,3- dif...)
Affinity DataIC50: 0.517nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
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Date in BDB:
7/10/2022
Entry Details
US Patent