BDBM543909 (1S,3'R,6'S,7'R,11'S,12'R)- 6-chloro-7'-((4-(2- methoxyethyl)-3-oxo- 1,4-diazepan-1- yl)methyl)-11',12'- dimethyl-3,4-dihydro- 2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]di- azatetracyclo[14.7.2.0~3, 6~.0~19,24~]pentacosa [16,18,24]trien]-15'-one 13',13'-dioxide AND::US11279712, Example 42

SMILES COCCN1CCCN(C[C@H]2CCC[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c3ccc4OC[C@]5(CCCc6cc(Cl)ccc56)CN(C[C@@H]5CC[C@@H]25)c4c3)CC1=O

InChI Key InChIKey=PWMXDDRRBFRYEZ-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 543909   

LigandPNGBDBM543909((1S,3'R,6'S,7'R,11'S,12'R)- 6-chloro-7'-((4-(2- me...)
Affinity DataIC50: 0.408nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
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Date in BDB:
7/10/2022
Entry Details
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