BDBM543916 (1s,3′r,6′r,7′r,8′e,11′s,12′r)-6-chloro-7′-((1r)-1-hydroxypropyl)-11′,12′-dimethyl-3,4-dihydro-2h,15′h-spiro[naphthalene-1,22′-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.0 3,6 0.0 19,24 ]pent acosa[8,16,18,24]tetraen]-15′-one 13′,13′-dioxide::US11279712, Example 49

SMILES CC[C@@H](O)[C@@H]1\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=GAWNCIQRXQHVLK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 543916   

LigandPNGBDBM543916((1s,3′r,6′r,7′r,8′e,11R...)
Affinity DataIC50: 0.377nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
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Date in BDB:
7/10/2022
Entry Details
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