BDBM543923 (1s,3′r,6's,7′r,11′s,12′r)-6-chloro-11′,12′-dimethyl-7′-(((9as)-8-methyloctahydro-2h-pyrazino[1,2-a]pyrazin-2-yl)methyl)-3,4-dihydro-2h,15′h-spiro[naphthalene-1,22′-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.03,60.019,24]pent acosa[16,18,24]trien]-15′-one 13′,13′-dioxide::US11279712, Example 56
SMILES C[C@H]1CCC[C@@H](CN2CCN3CCN(C)C[C@H]3C2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C
InChI Key InChIKey=JSHMKNAXSIFCCQ-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 543923
TargetBcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 0.520nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair