BDBM543929 (1S,3'R,6'R,7'R,8'E, 11'S,12'R)- 6-chloro-11',12'- dimethyl-7'-(4- morpholinylmethyl)-3,4- dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]di- azatetracyclo[14.7.2.0~3, 6~.0~19,24~]pentacosa [16,18,24]trien]-15'-one 13',13'-dioxide AND::US11279712, Example 62

SMILES C[C@H]1C\C=C\[C@H](CN2CCOCC2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C

InChI Key InChIKey=WIIQPCOKDVFNGD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 543929   

LigandPNGBDBM543929(US11279712, Example 62 | (1S,3'R,6'R,7'R,8'E, 11'S...)
Affinity DataIC50: 0.388nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
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Date in BDB:
7/10/2022
Entry Details
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