BDBM543968 7-(2-Amino-6- fluoro-phenyl)- 6-chloro-1-[4- (dimethylamino)- 2-isopropyl-3- pyridyl]-4- [(2S,5R)-2,5- dimethyl-4-prop- 2-enoyl- piperazin-1- yl]pyrido[2,3- d]pyrimidin-2- one::US11285156, Ex.# 55-54::US11285156, Ex.# 55-56::US11285156, Ex.# 55-57

SMILES CC(C)c1nccc(N(C)C)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1c(N)cccc1F

InChI Key InChIKey=LPDMIKZRLKUWEG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 543968   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM543968(US11285156, Ex.# 55-56 | US11285156, Ex.# 55-57 | ...)
Affinity DataIC50: 23nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM543968(US11285156, Ex.# 55-56 | US11285156, Ex.# 55-57 | ...)
Affinity DataIC50: 32nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM543968(US11285156, Ex.# 55-56 | US11285156, Ex.# 55-57 | ...)
Affinity DataIC50: 168nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent