BDBM544047 (M)-7-(2- Amino-6- fluoro-phenyl)- 6-chloro-1-(2- isopropyl-4- methyl-3- pyridyl)-4- [(3R)-3-methyl- 4-prop-2-enoyl- piperazin-1- yl]pyrido[2,3- d]pyrimidin-2- one::US11285156, Ex.# 92-11::US11285156, Ex.# 92-2

SMILES CC(C)c1nccc(C)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1cccc2cc[nH]c12

InChI Key InChIKey=CWHOBILUIYZWLN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 544047   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544047(US11285156, Ex.# 92-11 | (M)-7-(2- Amino-6- fluoro...)
Affinity DataIC50: 24nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544047(US11285156, Ex.# 92-11 | (M)-7-(2- Amino-6- fluoro...)
Affinity DataIC50: 86nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent