BDBM544164 1-(4,6- Diisopropylpyrimidin- 5-yl)-4-[(2S,5R)- 2,5-dimethyl-4- prop-2-enoyl- piperazin-1-yl]-6- fluoro-7-(2- fluorophenyl)pyrido [2,3-d]pyrimidin- 2-one::US11285156, Ex.# 101-2::US11306087, Ex. # 10

SMILES CC(C)c1ncnc(C(C)C)c1-n1c2nc(c(F)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1ccccc1F

InChI Key InChIKey=LGPIVYPLXNVRQZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 544164   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544164(US11285156, Ex.# 101-2 | 1-(4,6- Diisopropylpyrimi...)
Affinity DataIC50: 160nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetGTPase KRas [1-169,G12D](Human)
Amgen

US Patent
LigandPNGBDBM544164(US11285156, Ex.# 101-2 | 1-(4,6- Diisopropylpyrimi...)
Affinity DataIC50: 160nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2022
Entry Details
US Patent