BDBM544247 6-Chloro-1-(2,4- diisopropyl-3- pyridyl)-4-[(2S,5R)- 2,5-dimethyl-4-prop- 2-enoyl-piperazin-1- yl]-7-[2- (trifluoromethyl) phenyl]pyrido[2,3- d]pyrimidin-2-one::US11285156, Ex.# 124-3

SMILES CC(C)c1ccnc(C(C)C)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1ccccc1C(F)(F)F

InChI Key InChIKey=BZJMHUHOGZGQFI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544247   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544247(US11285156, Ex.# 124-3 | 6-Chloro-1-(2,4- diisopro...)
Affinity DataIC50: 28nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent