BDBM544268 6-Chloro-7-(2- chlorophenyl)-1- (2,4-diisopropyl-3- pyridyl)-4- [(2S,5R)-2,5- dimethyl-4-prop- 2-enoyl-piperazin- 1-yl]pyrido[2,3- d]pyrimidin-2-one::US11285156, Ex.# 125-6

SMILES CC(C)c1ccnc(C(C)C)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1ccccc1Cl

InChI Key InChIKey=AMEQTUQGBIGUCK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544268   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544268(US11285156, Ex.# 125-6 | 6-Chloro-7-(2- chlorophen...)
Affinity DataIC50: 38nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent