BDBM544375 4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-7-(2-amino-6-fluorophenyl)-1-(4-amino-6-isopropylpyrimidin-5-yl)-6-chloropyrido[2,3-d]pyrimidin-2(1H)-one::US11285156, Ex.# 192

SMILES COc1ccc(CN(Cc2ccc(OC)cc2)c2ncnc(C(C)C)c2-n2c3nc(Cl)c(Cl)cc3c(nc2=O)N2C[C@@H](C)N(C[C@@H]2C)C(=O)C=C)cc1

InChI Key InChIKey=YUFWZZPWRGTFLR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544375   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544375(US11285156, Ex.# 192 | 4-((2S,5R)-4-Acryloyl-2,5-d...)
Affinity DataIC50: 29nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent