BDBM547807 WO2022090481, Example I-022::WO2022090481, Example I-064

SMILES COCCN1CCN(CC1)c1nc2c(nc(cc2n1C)-n1ncc2c(C)nc(cc12)-c1cnccc1OC)N1C[C@H]2C[C@@H]1CO2

InChI Key InChIKey=NBILLXVMFPDPPM-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 547807   

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 1nMAssay Description: Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 27nMAssay Description: Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 2.94E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 2.71E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 3.70nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 7.80nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 5nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 7.40nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor [L858R](Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 19nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 12nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 34nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 14nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481