BDBM548334 WO2022093856, Example 1-29

SMILES CNC(=O)C[C@H](CC(C)C)Nc1nc(nc2CC(C)(C)CCc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=AELFPFVOWYGJLE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 548334   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

WIPO
LigandChemical structure of BindingDB Monomer ID 548334BDBM548334(WO2022093856, Example 1-29)
Affinity DataIC50: 57nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022093856

TargetGTPase KRas(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 548334BDBM548334(WO2022093856, Example 1-29)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant His-tagged GDP-bound human KRAS G12C/C118A mutant (1 to 169 residues) (unknown origin) extracted by Escherichia coli assess...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed