BDBM550325 2-(2-chloro-4-(2- ((1-(2,2-difluoro- ethyl)-4-fluoro- 1H-benzo[d]- imidazol-2-yl)- amino)-2-oxo- ethyl)phenoxy)- nicotinamide::US11306081, Example 173

SMILES NC(=O)c1cccnc1Oc1ccc(CC(=O)Nc2nc3c(F)cccc3n2CC(F)F)cc1Cl

InChI Key InChIKey=SQZOIPUKILNRFH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 550325   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM550325(2-(2-chloro-4-(2- ((1-(2,2-difluoro- ethyl)-4-fluo...)
Affinity DataIC50: 8nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
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Date in BDB:
7/31/2022
Entry Details
US Patent