BDBM550332 4-((2S,5R,M)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-6-chloro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one::US11306087, Ex. # 2

SMILES CC(C)c1nccc(C)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1c(O)cccc1F

InChI Key InChIKey=RRWKJUQUWYIBGK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 550332   

TargetGTPase KRas [1-169,G12D](Human)
Amgen

US Patent
LigandPNGBDBM550332(4-((2S,5R,M)-4-Acryloyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50: 27nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2022
Entry Details
US Patent