BDBM550352 4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-1-(4,6-diisopropylpyrimidin-5-yl)-6-fluoro-7-(2-fluorophenyl)pyrido[2,3-d]pyrimidin-2(1H)-one::US11306087, Ex. # 22

SMILES CC(C)c1ncnc(C(C)C)c1-n1c2nc(c(F)cc2c(nc1=O)N1C[C@H](C)N([C@H](C)C1)C(=O)C=C)-c1ccccc1F

InChI Key InChIKey=UKBDMRNUMSSWHE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 550352   

TargetGTPase KRas [1-169,G12D](Human)
Amgen

US Patent
LigandPNGBDBM550352(4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-1-(4...)
Affinity DataIC50: 560nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2022
Entry Details
US Patent