BDBM550799 8-(8-Fluoroquinolin-6-yl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine 7::US11312705, Example 7

SMILES Nc1nc(-c2ccccc2)c(-c2cc(F)c3ncccc3c2)c2nncn12

InChI Key InChIKey=JPFQHWSQTRSHLZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 550799   

TargetAdenosine receptor A2a(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550799(8-(8-Fluoroquinolin-6-yl)-7-phenyl-[1,2,4]triazolo...)
Affinity DataIC50: 0.160nMAssay Description:CHO-K1/A2aR cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 800 μg/ml bleomycin. The cells were digested with the c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550799(8-(8-Fluoroquinolin-6-yl)-7-phenyl-[1,2,4]triazolo...)
Affinity DataIC50: 0.160nMAssay Description:CHO-K1/A2aR cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 800 μg/ml bleomycin. The cells were digested with the c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetAdenosine receptor A3(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550799(8-(8-Fluoroquinolin-6-yl)-7-phenyl-[1,2,4]triazolo...)
Affinity DataIC50: 5nMAssay Description:CHO-K1/A3R cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 10 μg/ml puromycin. The cells were digested with the cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550799(8-(8-Fluoroquinolin-6-yl)-7-phenyl-[1,2,4]triazolo...)
Affinity DataIC50: 16nMAssay Description:CHO-K1/A1R cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 1 mg/ml G418. The cells were digested with the cell separatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent