BDBM551627 1-(4-((3R,5S or 3S,5R)-3-(5-amino-9-fluoro-7-methoxy- [1,2,4]triazolo[1,5-c]quinazolin-2-yl)-5-methylpiperidin- 1-yl)-5-methyl-1H-pyrazol-1-yl)-2-methylpropan-2-ol::US11312719, Example 173::US11312719, Example 174

SMILES COc1cc(F)cc2c3nc(nn3c(N)nc12)C1CC(C)CN(C1)c1cnn(CC(C)(C)O)c1C

InChI Key InChIKey=JRPAGDUZNIVMGV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 551627   

TargetAdenosine receptor A2a(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM551627(1-(4-((3R,5S or 3S,5R)-3-(5-amino-9-fluoro-7-metho...)
Affinity DataIC50: 20.7nMAssay Description:The ability of compounds to antagonize human A2A and A2B adenosine receptors was determined using a kit to measure changes in intracellular cyclic AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetAdenosine receptor A2b(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM551627(1-(4-((3R,5S or 3S,5R)-3-(5-amino-9-fluoro-7-metho...)
Affinity DataIC50: 2.02E+3nMAssay Description:The ability of compounds to antagonize human A2A and A2B adenosine receptors was determined using a kit to measure changes in intracellular cyclic AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM551627(1-(4-((3R,5S or 3S,5R)-3-(5-amino-9-fluoro-7-metho...)
Affinity DataIC50: 0.600nMAssay Description:The ability of compounds to antagonize human A2A and A2B adenosine receptors was determined using a kit to measure changes in intracellular cyclic AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetAdenosine receptor A2b(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM551627(1-(4-((3R,5S or 3S,5R)-3-(5-amino-9-fluoro-7-metho...)
Affinity DataIC50: 30.7nMAssay Description:The ability of compounds to antagonize human A2A and A2B adenosine receptors was determined using a kit to measure changes in intracellular cyclic AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent