BDBM552732 (2S,4R)-1-((S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-3,3-dimethylhutanoyl)-4-hydroxypyrrolidine-2-carhoxamide (Compound 1)::WO2022104345, Example S1

SMILES CC(C)(C)[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(N)=O)n1cc(nn1)C1CC1

InChI Key InChIKey=CGXDADSNPGGRLO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552732   

LigandPNGBDBM552732((2S,4R)-1-((S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1...)
Affinity DataIC50: 1.17E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex is measured using a fluorescence polarization tracer competition assay. The VHL / Elongi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345

LigandPNGBDBM552732((2S,4R)-1-((S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1...)
Affinity DataIC50: 2.00E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345