BDBM552757 (2S,4R)-4-hydroxy-1-((S)-2-(4-methoxy-1H-benzo[d][1,2,3]triazol-1-yl)-3-methylbutanoyl)-N-methylpyrrolidine-2-carboxamide (Compound 28) and (2S,4R)-4-hydroxy-1-((R)-2-(4-methoxy-1H-benzo[d][1,2,3]triazol-1-yl)-3-methylbutanoyl)-N-methylpyrrolidine-2-carboxamide (compound 29) Synthesis was carried out following the scheme given below:::WO2022104345, Compound 28::WO2022104345, Example S25

SMILES CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)C)n1nnc2c(OC)cccc12

InChI Key InChIKey=LVCPBAHKWBSXAE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 552757   

LigandPNGBDBM552757(WO2022104345, Compound 28 | (2S,4R)-4-hydroxy-1-((...)
Affinity DataIC50: 2.60E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104345