BDBM554453 US11332492, Example 2

SMILES O[C@@H]1[C@@H](COCP(O)(O)=O)O[C@H]([C@@H]1O)n1ncc2c(nc(Cl)nc12)N1CC2(C1)CCc1ccccc21

InChI Key InChIKey=NAHILNAHEKBGES-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 554453   

Target5'-nucleotidase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM554453(US11332492, Example 2)
Affinity DataIC50: 0.0130nMAssay Description:I. Experimental Materials and Equipment1. Malachite green phosphate detection kit (R & D Systems, Cat #, DY996)2. Recombinant human 5′-nucleoti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details
US Patent

Target5'-nucleotidase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM554453(US11332492, Example 2)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human CD73 expressed in A-375 cells incubated for 15 mins by malachite green based spectrophotometer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target5'-nucleotidase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM554453(US11332492, Example 2)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human CD73More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM554453(US11332492, Example 2)
Affinity DataIC50: 0.0510nMAssay Description:Inhibition of human CD73 expressed in A-375 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM554453(US11332492, Example 2)
Affinity DataIC50: 50nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant CD73 expressed in CHO cells incubated for 1 hr by malachite green based spectrophotometer assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed