BDBM555574 US11344553, Compound 3

SMILES CCS(=O)(=O)NCc1ccc(cc1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key InChIKey=VFWZEMIPXRZJDU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 555574   

TargetHigh affinity nerve growth factor receptor(Human)
Teligene

US Patent
LigandPNGBDBM555574(US11344553, Compound 3)
Affinity DataIC50: 3nMAssay Description:I. Prepare 1× Kinase Base Buffer and Stop Buffer for Testing Kinases1) 1× Kinase base buffer (for TRK-A)50 mM HEPES, pH 7.50.0015% Brij-352) Stop buf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Teligene

US Patent
LigandPNGBDBM555574(US11344553, Compound 3)
Affinity DataIC50: 104nMAssay Description:I. Prepare 1× Kinase Base Buffer and Stop Buffer for Testing Kinases1) 1× Kinase base buffer (for TRK-A)50 mM HEPES, pH 7.50.0015% Brij-352) Stop buf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent