BDBM555844 1-((3S,5R)-1-acryloyl-5- methoxymethyl)pyrrolidin-3-yl)-3-((1-cyclopropyl-2-methyl-1H-benzo[d]imidazol-5-yl)ethynyl)-5-(methylamino)-1H-pyrazole-4-carboxamide::US11345681, Example 12

SMILES CNc1c(C(N)=O)c(nn1[C@H]1C[C@H](COC)N(C1)C(=O)C=C)C#Cc1ccc2n(C3CC3)c(C)nc2c1

InChI Key InChIKey=WIQBEPAALNQBFG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 555844   

TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555844(US11345681, Example 12 | 1-((3S,5R)-1-acryloyl-5- ...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of wild type FGFR2 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555844(US11345681, Example 12 | 1-((3S,5R)-1-acryloyl-5- ...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of wild type FGFR1 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555844(US11345681, Example 12 | 1-((3S,5R)-1-acryloyl-5- ...)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of wild type FGFR3 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555844(US11345681, Example 12 | 1-((3S,5R)-1-acryloyl-5- ...)
Affinity DataIC50: 16nMAssay Description:Inhibition of FGFR2 V564F mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555844(US11345681, Example 12 | 1-((3S,5R)-1-acryloyl-5- ...)
Affinity DataIC50: 20nMAssay Description:Inhibition of FGFR3 V555M mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555844(US11345681, Example 12 | 1-((3S,5R)-1-acryloyl-5- ...)
Affinity DataIC50: 53nMAssay Description:Inhibition of FGFR3 K650M mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555844(US11345681, Example 12 | 1-((3S,5R)-1-acryloyl-5- ...)
Affinity DataIC50: 54nMAssay Description:Inhibition of FGFR2 N549H mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555844(US11345681, Example 12 | 1-((3S,5R)-1-acryloyl-5- ...)
Affinity DataIC50: 100nMAssay Description:Small molecule inhibition of FGFR2 kinase activity was evaluated using a fluorescence-based microfluidic mobility shift assay. FGFR2 catalyzes the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent