BDBM556330 N-(5-((1-ethylpiperidin-4-yl)methoxy)pyridin-2-yl)-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyridin-2-amine (Compound 60)::US11351170, Example 9

SMILES CCN1CCC(COc2ccc(Nc3cc(c(F)cn3)-c3cc(F)c4nc5CCC(C)(C)n5c4c3)nc2)CC1

InChI Key InChIKey=DCRIEDZZYPOGPK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 556330   

TargetCyclin-dependent kinase 4(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556330(US11351170, Example 9 | N-(5-((1-ethylpiperidin-4-...)
Affinity DataIC50: 0.100nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 6(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556330(US11351170, Example 9 | N-(5-((1-ethylpiperidin-4-...)
Affinity DataIC50: 2.90nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were respectively dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 2(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556330(US11351170, Example 9 | N-(5-((1-ethylpiperidin-4-...)
Affinity DataIC50: 24.7nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetCyclin-dependent kinase 5(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556330(US11351170, Example 9 | N-(5-((1-ethylpiperidin-4-...)
Affinity DataIC50: 11.3nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent